Batch Processing

NC-Scorer includes a powerful batch processing feature to analyze multiple variants simultaneously.

Accessing Batch Mode

Click the "Batch" item in the main navigation menu or navigate to /batch.

Input Format

Enter variants one per line with optional inheritance and segregation data:

# Basic format (variant only)
NM_001009944.3:c.11798G>A

# With inheritance pattern
NM_001009944.3:c.11798G>A	Inherited dominant

# With inheritance and segregation
NM_001009944.3:c.11798G>A	Inherited dominant	0.05

Supported Variant Formats

• HGVS: NM_001009944.3:c.11798G>A
• Genomic: chr16:2138253:G:A
• rsID: rs121913240

Inheritance Patterns

• Denovo
• Inherited dominant
• Homozygous recessive
• Compound heterozygous (confirmed/suspected)
• X-linked dominant/recessive
• Unknown

Processing

1. Enter variants in the text area
2. Or click "Fill with Examples" for sample data
3. Select output format (CSV, TSV, JSON, VCF)
4. Click "Process & Download"

Limits

• Maximum 200 variants per batch
• Processing time depends on API response times
• Progress indicator shows current status

Export Formats

CSV/TSV

Spreadsheet-compatible format with all scores and annotations.

JSON

Structured data format for programmatic processing:

{
  "variant": "NM_001009944.3:c.11798G>A",
  "gene": "PKD1",
  "scores": {
    "ncs": 8.5,
    "gene": 0.9,
    "variant": 0.85,
    "inheritance": 0.8
  }
}

VCF

Standard variant call format for genomic pipelines.

Tips

• Pre-validate variant formats to avoid errors
• Include segregation data for inherited patterns to avoid penalties
• Use consistent inheritance terminology
• Export results immediately after processing